Breast cancer is the most common malignancy among Indian women and has surpassed cervical cancer. As increasing numbers of breast cancer patients become long-term survivors, there must be a greater focus on treatment-induced chronic toxicities. Cardio-oncology is an emerging area which deals with the cardiovascular side effects of cancer therapy. Cardiovascular ischemia, congestive heart failure, thrombosis and hypertension are some of the problems under the treatment of certain chemotherapy drugs. Understanding the molecular mechanism of vascular dysfunctions associated with cancer treatment will help to improve the quality of life for cancer survivors. Gajalakshmi's lab studies and dissects mechanistic insights of "cardio-oncology".
1. Study of the effects of breast cancer drugs on endothelial cells and nitric oxide signaling (Abstract)
2. Comparative nitric oxide profiling of blood and malignant tissue in cancer patients (Abstract)
1. Role of gap junctions in the bystander effect in breast cancer cells (Abstract)
2. Screening for BRCA1 mutations in hereditary breast cancer patients in Tamil Nadu (Abstract)