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AU-KBC RESEARCH CENTRE

Dr. Aparajita Dey

 

Educational experience and training

 

M.Sc Biochemistry,B.H.U, India ( 1995)

Ph.D Biochemistry, Industrial Toxicology Research Centre & B.H.U., India (1997-2002)

Postdoctoral Fellow (Dr. John D Imig), Vascular Biology Center, Medical College of Georgia, Augusta, U.S.A (2002-2004)

Postdoctoral Fellow (Dr. Arthur I Cederbaum), Department of Pharmacology & Biological Chemistry, Mount Sinai School of Medicine, New York, USA (2004-2007).

 

Fellowships

 

Graduate Aptitude Test in Engineering (GATE) Fellowship: 1995

Council of Scientific and Industrial Research (CSIR)-University Grants Commission (UGC) National Eligibility Test Fellowship: 1996

National Kidney Foundationof Georgia Postdoctoral Fellowship : 2003

 

Research Interests

 

Cytochrome P450 biology & toxicology

Alcohol mediated liver injury

Obesity & diabetes

 

Lab Members

 

MS Students

Karthikeyan Chandrasekaran

 

Phd Students

Kavitha Swaminathan - JRF (CSIR) January 2009 - Till Date

S Mathan Kumar January 2010 - Till Date

 

Project Fellows

S Mathan Kumar DBT - RGYI (JRF) - 2010-2012

J. Lakshmanan DST - FAST TRACK - 2010-2012

 

 

Positions Open

 

M.S., Ph.D

 

Publications

 

1.       Cytochrome P4501A1 in rat blood lymphocytes: Evidence for catalytic activity and mRNA expression. Dey A, Parmar D, Dayal M. Dhawan A & Seth PK.Life Sciences 69: 383-393 (2001).

 

1.       Cytochrome P4502E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.Dey A, Parmar D, Dhawan A,Dash D& Seth PK. Life Sciences 71: 2509-2519 (2002).

 

2.       Kidney damage in obesity related diabetes: involvement of arachidonic acid metabolites. Dey A & Imig JD. Recent Research Developments in Physiology 2: 95-107 (2004).

 

3.       Decreased CYP2C and increased COX-2 are associated with obesity-related kidney damage. Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD & Imig JD. Obesity Research 12(8):1278-1289 (2004).

 

4.       Rofecoxib decreases renal injury in obese Zucker rats. Dey A, Maric C, Kaesemeyer WH, Zaharis CZ, Stewart J, Pollock JS, Imig JD. Clinical Science 107(6):561-570 (2004).

 

5.       Decreased epoxygenase and increased epoxide hydrolase expression in mesenteric artery of Obese Zucker rats. Zhao X, Dey A, Romanko OP, Stepp DW, Wang MH, Zhou Y, Jin L, Pollock JS, Webb RC, Imig JD. American Journal of Physiology Regulatory Integrative and Comparative Physiology. 288(1):R188-R196 (2005).

 

6.       Evidence for cytochrome P450 2E1 catalytic activity and expression in rat blood lymphocytes. Dey A, Dhawan A, Seth PK & Parmar D. Life Sciences 77(10):1082-1093 (2005).

 

7.       CYP450, COX and Obesity Related Renal Damage. Imig JD, Zhao X, Dey A & Shaw M. Toxicology Mechanisms and Methods. 15: 125-136 (2005).

 

8.       Alcohol & Oxidative Liver Injury. Dey A & Cederbaum AI. Hepatology. 43(2 Suppl 1):S63-74 (2006).

 

9.       Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1. Dey A, Kessova IG,���� Cederbaum AI. Archives of Biochemistry & Biophysics. 447(2):155-66 (2006).

 

10.   Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1 mediated toxicity in HepG2 cells. Dey A & Cederbaum AI. Journal of Pharmacology & Experimental Therapeutics. 317 (3):1391-1399 (2006).

 

11.   Evidence for Cytochrome P450 3A Expression and Catalytic Activity in Rat Blood Lymphocytes. Dey A, Yadav S, Dhawan A, Seth PK & Parmar D. Life Sciences 79(18):1729-1735 (2006).

 

12.   Geldanamycin, an inhibitor of Hsp90 potentiates CYP2E1 toxicity in HepG2 cells through the sustained activation of p38MAPK pathway. Dey A & Cederbaum AI. Archives of Biochemistry & Biophysics. 2007 461(2):275-86 (2007).

 

13.   Induction of CYP2E1 potentiates liver injury in ob/ob mice. Dey A & Cederbaum AI. Hepatology. 45(6):1355-1365 (2007).

 

14.   S-adenosylmethionine prevents CYP2E1 mediated liver injury in ob/ob mice. Dey A & Cederbaum AI. American Journal of Physiology- Gastrointestinal and Liver Physiology. 0000 (2007).