Genetic Polymorphism and Breast
Polymorphic low penetrance genes along with lifestyle and environmental risk factors are responsible for almost 90% of sporadic breast cancer. Several studies have been conducted on the genetic polymorphic aspects of the disease. Genotoxic compounds implicated in cancer initiation include
These carcinogens (cancer causing agents) are metabolized by the enzymes such as Cytochrome p450, N-Acetyl Transferase and Glutathione S-Transferase and are expressed by the mammary gland. The effect of polymorphisms in the genes encoding these enzymes increase the breast cancer risk and are shown in the table.
|Cytochrome P450 (CYPs)||
|Polycyclic aromatic hydrocarbons and Heterocyclic amines||C - (or) N - hydroxylation||, , |
|N - Acetyl Transferase (NAT)||NAT1,NAT2||Heteroyclic Amines||O - Acetylation||, |
|Glutathione S-Transferase (GST)||
|Heterocyclic Amines||--||, , ,, ,|
A number of environmental chemicals also play a role in breast cancer initiation which include organochlorines, chlorinated pesticides, polychlorinated biphenyls and polychlorinated dibenzo compounds. They mimic the properties of estrogen which plays an important role in cell differentiation. , .
Another common genetic variant which increases the risk of breast
cancer include Ataxia Telengiectasia which is caused by disruption of ATM
located on the chromosome 11q22-q23. CtIP is a protein involved in DNA
repair machinery and interacts with BRCA1 in regulating the expression of
p21 and GADD45 genes. Upon ionizing radiation, the BRCA1 associated
CtIP, becomes hyperphosphorylated and gets dissociated from BRCA1. This
triggers a defect in DNA repair pathway resulting in uncontrolled cell